open positions

• Senior Data Scientist

  San Diego, CA or Remote

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  Position Description: Empirico, a clinical-stage biotechnology company that combines unmatched expertise in human genetics-driven target discovery with world-class capabilities in siRNA medicines, is looking for a talented data scientist experienced in human genetics and bioinformatics who is interested in applying these skills towards interpreting large scale human genetics data for the purpose of therapeutic target discovery. This is an excellent opportunity for a highly-motivated, creative data scientist to be a vital member of a team of experts dedicated to identifying new therapeutic targets and translating those insights into drug discovery and development programs.

  Responsibilities:

  Your responsibilities will primarily consist of performing analyses and building robust computational pipelines and tools critical to Empirico’s target discovery efforts. You will be expected to –

  • Collaborate closely with a multidisciplinary team consisting of human geneticists, biologists, bioinformatics scientists and software engineers, and use your data analysis skills to gain insights from massive genetic datasets
  • Work independently and as part of a team to complete projects related to:
    • Deploying robust, scalable data analysis pipelines, software tools, and web applications to support target discovery – including innovative methods to analyze genetic and phenotypic data
    • Implementing cutting-edge analytical methods and algorithms (both internally-developed and those described in the literature)
    • Integrating, analyzing and visualizing large, complex data sets to extract information useful to our target discovery efforts
  • Perform focused genetic analyses to gain insights into novel target biology and clearly communicate these analyses to Empirico colleagues
  • Perform analyses to address critical platform/application QC

  Requirements:

  • This position requires a MS or PhD in bioinformatics or a related discipline (e.g. computer science)
  • Core background MUST be in data science or bioinformatics; this position is NOT for scientists with a primarily wet-lab background
  • Strong skills in at least one programming language (preferably Python)
  • Familiarity with Linux command-line based tools and bash scripting
  • Experience using HPC/cloud computing environments (AWS, Azure, GCP)
  • Demonstrated experience processing, analyzing, and visualizing genetic datasets to make scientific insights
  • A strong understanding of applied statistical methods and the principles of statistical genetics
  • Experience working with RNA-seq (or scRNA-seq), GWAS data, and other omics data types a plus
  • Experience working with UK Biobank data or other large-scale biomedical databases a plus
  • Full stack development experience a plus, but not expected
  • Comfortable with version control systems such as Git
  • Demonstrated ability for writing readable, testable, and SOLID code
  • Applicants must have authorization to work in the U.S.

  The estimated annual base salary range for this role is $80,000 to $150,000.  Individual compensation decisions will be based on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills.  We offer a wide range of benefits including a retirement savings plan (with company match), paid vacation, holidays, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.

  About Empirico: Empirico is a clinical-stage biotechnology company that discovers and develops novel medicines designed to mimic naturally-occurring genetic variants that confer beneficial effects on health and disease. Empirico’s two foundational technology platforms – the Precision Insights Platform™ for genetically-validated target discovery, and the siRCH™ platform for the discovery and development of siRNA medicines – are used separately and in tandem to enable Empirico and our collaborators from the discovery and validation of novel targets to clinically-viable therapeutics. Empirico’s exceptional internal capabilities, augmented by those of its partners, are driving the advancement of a growing and differentiated pipeline of wholly-owned and partnered programs. Empirico is headquartered in San Diego, CA with a major second site in Madison, WI.

  We’re striving to build a strong culture of inclusivity, transparency and collaboration at Empirico, where our diverse and equitable workforce is empowered to contribute to our mission. We always seek the best candidate for the position and encourage you to apply even if your experience or qualifications don’t match up exactly with the job description. Empirico is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

  To All Agencies: Please do not contact any employee of Empirico about this position. All resumes submitted by agencies to any employee of Empirico via-email or in any form and by any method will be deemed the sole property of Empirico, unless such agencies were engaged by Empirico for this position and a valid agreement is in place.

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• Bioinformatics Scientist

  San Diego, CA

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  Position Description: Empirico, a clinical-stage biotechnology company that combines unmatched expertise in human genetics-driven target discovery with world-class capabilities in siRNA medicines, is looking for a talented bioinformatics scientist with software development skills. This individual will play a pivotal role in building and extending Empirico’s internal software platform focused on storing, analyzing, and managing data crucial to our drug design process.

  Responsibilities:

  Your responsibilities will include the development of software solutions critical to Empirico’s drug discovery efforts. You will be expected to –

  • Assist in developing and maintaining Empirico’s internal software platform used to store, retrieve, and analyze datasets relevant to the design and evaluation of therapeutic molecules
  • Collaborate with cross-functional teams to define software requirements, integrate scientific workflows and experimental data into the platform, and facilitate advanced data analysis
  • Employ software development best practices to develop robust, scalable, and maintainable code
  • Ensure our platform meets quality standards by conducting code reviews and leading internal testing and debugging efforts
  • Work closely with team members to identify and address software platform needs, improve process efficiency, and ensure data integrity
  • Manage the integration of large, complex biological datasets, ensuring efficient data processing, storage, and retrieval capabilities
  • Communicate technical and complex information effectively to a diverse audience of software engineers, computational and wet lab scientists, and drug developers

  Requirements:

  • This position requires a Bachelor’s or Master’s degree in bioinformatics or a related discipline (e.g., computer science, mathematics), with 0-3 years of relevant experience
  • Proficient in at least one programming language (preferably Python or JavaScript)
  • Experience with frontend frameworks, such as React
  • Experience with database management systems such as PostgreSQL or MySQL
  • Experience processing, analyzing, and visualizing biological datasets
  • Familiarity with the use of version control systems such as Git
  • Demonstrated ability for writing readable, testable, and SOLID code
  • Experience using cloud computing environments (AWS, Azure, GCP) is a plus
  • An ideal candidate is self-motivated and can learn and work independently
  • Applicants must have authorization to work in the U.S.

  The estimated annual base salary range for this role is $80,000 to $110,000.  Individual compensation decisions will be based on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills.  We offer a wide range of benefits including a retirement savings plan (with company match), paid vacation, holidays, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.

  About Empirico: Empirico is a clinical-stage biotechnology company that discovers and develops novel medicines designed to mimic naturally-occurring genetic variants that confer beneficial effects on health and disease. Empirico’s two foundational technology platforms – the Precision Insights Platform™ for genetically-validated target discovery, and the siRCH™ platform for the discovery and development of siRNA medicines – are used separately and in tandem to enable Empirico and our collaborators from the discovery and validation of novel targets to clinically-viable therapeutics. Empirico’s exceptional internal capabilities, augmented by those of its partners, are driving the advancement of a growing and differentiated pipeline of wholly-owned and partnered programs. Empirico is headquartered in San Diego, CA with a major second site in Madison, WI.

  We’re striving to build a strong culture of inclusivity, transparency and collaboration at Empirico, where our diverse and equitable workforce is empowered to contribute to our mission. We always seek the best candidate for the position and encourage you to apply even if your experience or qualifications don’t match up exactly with the job description. Empirico is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

  To All Agencies: Please do not contact any employee of Empirico about this position. All resumes submitted by agencies to any employee of Empirico via-email or in any form and by any method will be deemed the sole property of Empirico, unless such agencies were engaged by Empirico for this position and a valid agreement is in place.

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• Assistant Scientist - Drug Discovery

  Madison, WI

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  Position Description: Empirico, a clinical-stage biotechnology company that combines unmatched expertise in human genetics-driven target discovery with world-class capabilities in siRNA medicines, is looking for a talented scientist to join our Drug Discovery team and help advance our growing pipeline. This is an excellent opportunity to make meaningful contributions to the discovery and validation of novel therapeutic targets. You will work closely with other scientists that have a passion for finding new approaches toward the treatment and prevention of disease.

  Responsibilities:

  Your responsibilities will include performing different bioanalytical assays intended to provide key study readouts around biodistribution, pharmacokinetics, and pharmacodynamic biomarkers. The ideal candidate will have experience in both protein- and nucleic acid-based assays, be highly organized, and enjoy working in a team environment. You will be expected to –

  • Perform qPCR-based and immunoassay-based molecular assays to assess drug biodistribution, pharmacokinetics, and pharmacodynamics
  • Process animal tissues for downstream assay analyses
  • Aid in the creation of experimental protocols and SOPs
  • Maintain detailed experimental records
  • Analyze and communicate experimental results
  • Perform general laboratory duties including sample management and the ordering of reagents/supplies
  • Be a team player who enjoys an open environment where you can contribute in highly meaningful and impactful ways

  Requirements:

  • This position requires a Bachelor’s degree in Molecular Biology, Biochemistry or a related discipline, with at least one year relevant work experience in a laboratory setting
  • Experience with tissue processing and nucleic acid extraction
  • Experience with western blotting, RT-qPCR, gel electrophoresis
  • Experience with ELISA, AlphaLISA, reporter gene systems is a plus
  • Proficiency in MS Word, Excel and PowerPoint
  • Applicants must have authorization to work in the U.S.

  The estimated annual base salary range for this role is $50,000 to $65,000. Individual compensation decisions will be based on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. We offer a wide range of benefits including a retirement savings plan (with company match), paid vacation, holidays, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.

  About Empirico: Empirico is a clinical-stage biotechnology company that discovers and develops novel medicines designed to mimic naturally-occurring genetic variants that confer beneficial effects on health and disease. Empirico’s two foundational technology platforms – the Precision Insights Platform™ for genetically-validated target discovery, and the siRCH™ platform for the discovery and development of siRNA medicines – are used separately and in tandem to enable Empirico and our collaborators from the discovery and validation of novel targets to clinically-viable therapeutics. Empirico’s exceptional internal capabilities, augmented by those of its partners, are driving the advancement of a growing and differentiated pipeline of wholly-owned and partnered programs. Empirico is headquartered in San Diego, CA with a major second site in Madison, WI.

  We’re striving to build a strong culture of inclusivity, transparency and collaboration at Empirico, where our diverse and equitable workforce is empowered to contribute to our mission. We always seek the best candidate for the position and encourage you to apply even if your experience or qualifications don’t match up exactly with the job description. Empirico is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

  To All Agencies: Please do not contact any employee of Empirico about this position. All resumes submitted by agencies to any employee of Empirico via-email or in any form and by any method will be deemed the sole property of Empirico, unless such agencies were engaged by Empirico for this position and a valid agreement is in place.

  APPLY NOW

• General Application

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  We’re always looking for talented people who share our passion for improving patients’ lives. If you feel driven to contribute but don’t see an open position that fits your specific background and skills, let us know using the link below.

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