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help us discover
a new generation
of medicines

drug hunting is in our DNA

We are physicians, biologists, chemists, data scientists and drug developers – every one of us laser focused on transforming the lives of patients with innovative medicines.

If you thrive in a fun, fast-paced and highly collaborative environment, you’ll love working with us at Empirico. We offer competitive salaries and benefits, meaningful stock ownership and the opportunity to live and work in two of America’s greatest biotech cities – San Diego, California and Madison, Wisconsin.

We’re always looking for talented people who share our passion for improving patients’ lives. If you feel driven to contribute but don’t see an open position that fits your specific background or skills, let us know at careers@empiricotx.com.

open positions

  • Senior Data Scientist - Bioinformatics

    San Diego, CA or Remote
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    Position Description: Empirico, a biotechnology company that combines unmatched expertise in human genetics-driven target discovery with world-class capabilities in siRNA drug discovery, is looking for a talented data scientist experienced in human genetics and bioinformatics who is interested in applying these skills towards interpreting large scale human genetics data for the purpose of therapeutic target discovery. This is an excellent opportunity for a highly-motivated, creative data scientist to be a vital member of a team of experts dedicated to identifying new therapeutic targets and translating those insights into drug discovery and development programs.

    Responsibilities:

    Your responsibilities will primarily consist of performing analyses and building robust computational pipelines and tools critical to Empirico’s target discovery efforts. You will be expected to –

    • Collaborate closely with a multidisciplinary team consisting of human geneticists, biologists, bioinformatics scientists and software engineers, and use your data analysis skills to gain insights from massive genetic datasets
    • Work independently and as part of a team to complete projects related to:
      • Deploying robust, scalable data analysis pipelines, software tools, and web applications to support target discovery – including innovative methods to analyze genetic and phenotypic data
      • Implementing cutting-edge analytical methods and algorithms (both internally-developed and those described in the literature)
      • Integrating, analyzing and visualizing large, complex data sets to extract information useful to our target discovery efforts
    • Perform focused genetic analyses to gain insights into novel target biology and clearly communicate these analyses to Empirico colleagues
    • Perform analyses to address critical platform/application QC

    Requirements:

    • This position requires a MS or PhD in bioinformatics or a related discipline (e.g. computer science)
    • Core background MUST be in data science or bioinformatics; this position is NOT for scientists with a primarily wet-lab background
    • Strong skills in at least one programming language (preferably Python)
    • Familiarity with Linux command-line based tools and bash scripting
    • Experience using HPC/cloud computing environments (AWS, Azure, GCP)
    • Demonstrated experience processing, analyzing, and visualizing genetic datasets to make scientific insights
    • A strong understanding of applied statistical methods and the principles of statistical genetics
    • Experience working with RNA-seq (or scRNA-seq), GWAS data, and other omics data types a plus
    • Experience working with UK Biobank data or other large-scale biomedical databases a plus
    • Full stack development experience a plus, but not expected
    • Comfortable with version control systems such as Git
    • Demonstrated ability for writing readable, testable, and SOLID code
    • Applicants must have authorization to work in the U.S.

    The estimated base salary range for this role is $80,000 to $150,000.  Individual compensation decisions will be based on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills.  We offer a wide range of benefits including a retirement savings plan (with company match), paid vacation, holidays, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.

    About Empirico: Empirico is a biotechnology company that discovers and develops novel medicines designed to mimic naturally-occurring genetic variants that confer beneficial effects on health and disease. Empirico’s two foundational technology platforms – the Precision Insights Platform™ for genetically-validated target discovery, and the siRCH™ platform for the discovery and development of siRNA medicines – are used separately and in tandem to enable Empirico and our collaborators from the discovery and validation of novel targets to clinically-viable therapeutics. Empirico’s exceptional internal capabilities, augmented by those of its partners, are driving the advancement of a growing and differentiated pipeline of wholly-owned and partnered programs. Empirico is headquartered in San Diego, CA with a major second site in Madison, WI.

    We’re striving to build a strong culture of inclusivity, transparency and collaboration at Empirico, where our diverse and equitable workforce is empowered to contribute to our mission. We always seek the best candidate for the position and encourage you to apply even if your experience or qualifications don’t match up exactly with the job description. Empirico is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

    To All Agencies: Please do not contact any employee of Empirico about this position. All resumes submitted by agencies to any employee of Empirico via-email or in any form and by any method will be deemed the sole property of Empirico, unless such agencies were engaged by Empirico for this position and a valid agreement is in place.

    APPLY NOW
  • Scientist/Senior Scientist - Translational Genetics

    San Diego, CA
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    Position Description: Empirico, a biotechnology company that combines unmatched expertise in human genetics-driven target discovery with world-class capabilities in siRNA drug discovery, is looking for a talented human geneticist skilled in the analysis and interpretation of large-scale human genetics data for therapeutic target discovery. The ideal candidate will apply their background and experience in genetics, molecular biology and disease pathophysiology towards both identifying novel therapeutic targets and formulating mechanistic hypotheses that can be evaluated experimentally. This is an excellent opportunity for a highly motivated, creative scientist to be a vital member of our team.

    Responsibilities:

    Your responsibilities will include leveraging large-scale human genetics data to identify, evaluate, and conceptualize novel therapeutic targets, and helping to translate these insights into therapeutic programs. You will be expected to –

    • Lead the design, execution, and interpretation of human genetic analyses in pursuit of novel therapeutic targets
    • Apply established and novel analytical approaches for the identification of genetic associations with human health and disease
    • Translate findings from human genetic analyses into therapeutic hypotheses with plausible mechanistic underpinnings, that are supported by orthogonal evidence and that can be evaluated experimentally
    • Work collaboratively with cross-functional teams of geneticists, bioinformaticians, biologists, chemists, and drug developers to design and execute in silico, in vitro and in vivo studies to explore and validate therapeutic hypotheses
    • Communicate genetic discoveries internally and externally through expert-level presentations and the preparation of manuscripts for peer-reviewed publication
    • Provide novel ideas and critical thinking for the continued development and improvement of Empirico’s drug discovery platforms
    • Survey the latest developments in the broader genetics community and incorporate relevant approaches and findings into internal efforts

    Requirements:

    • This position requires a PhD in Human Genetics, Biomedical Informatics, or a related discipline, or a Master’s degree in combination with at least one year of experience in human genetics research with a translational focus
    • Demonstrated ability to design, lead, interpret, and communicate the results of human genetics studies, and to discern therapeutically-relevant hypotheses
    • A firm understanding of the principles of statistical genetics and genetic epidemiology
    • Though a background in molecular biology is preferred, familiarity with the design of experimental studies performed to understand the functional impact of genetic variants and the mechanistic basis for genetic associations is a must; however this position is NOT for applicants with primarily a wet-lab background
    • Applicants must have authorization to work in the U.S.

    The estimated base salary range for this role is $80,000 to $130,000. Individual compensation decisions will be based on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. We offer a wide range of benefits including a retirement savings plan (with company match), paid vacation, holidays, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.

    About Empirico: Empirico is a biotechnology company that discovers and develops novel medicines designed to mimic naturally-occurring genetic variants that confer beneficial effects on health and disease. Empirico’s two foundational technology platforms – the Precision Insights Platform™ for genetically-validated target discovery, and the siRCH™ platform for the discovery and development of siRNA medicines – are used separately and in tandem to enable Empirico and our collaborators from the discovery and validation of novel targets to clinically-viable therapeutics. Empirico’s exceptional internal capabilities, augmented by those of its partners, are driving the advancement of a growing and differentiated pipeline of wholly-owned and partnered programs. Empirico is headquartered in San Diego, CA with a major second site in Madison, WI.

    We’re striving to build a strong culture of inclusivity, transparency and collaboration at Empirico, where our diverse and equitable workforce is empowered to contribute to our mission. We always seek the best candidate for the position and encourage you to apply even if your experience or qualifications don’t match up exactly with the job description. Empirico is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

    To All Agencies: Please do not contact any employee of Empirico about this position. All resumes submitted by agencies to any employee of Empirico via-email or in any form and by any method will be deemed the sole property of Empirico, unless such agencies were engaged by Empirico for this position and a valid agreement is in place.

    APPLY NOW
  • Assistant Scientist - Target Biology

    San Diego, CA
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    Position Description: Empirico, a biotechnology company that combines unmatched expertise in human genetics-driven target discovery with world-class capabilities in siRNA drug discovery, is looking for a talented scientist to support our drug discovery programs.

    Responsibilities:

    Your responsibilities will include supporting in vitro pharmacology efforts that aim to elucidate novel drug target mechanisms and establish causal relationships between drug target modulation and disease. The ideal candidate will have in vitro cell and molecular biology experience. You will be expected to –

    • Conduct rigorous experiments, including cell-based and biochemical assays, to explore novel drug targets, aimed at yielding definitive yes/no answers
    • Possess working knowledge of molecular biology and cell culture systems
    • Maintain a highly organized and detailed lab notebook record of experimental activities
    • Independently analyze data, think critically through results, and interpret experimental findings
    • Communicate clearly in a written and verbal format
    • Act as a team player, committed to fostering a collaborative, transparent, and productive work environment

    Requirements:

    • This position requires a Bachelor’s degree in Cell Biology, Molecular Biology, Biochemistry, Physiology, or related field
    • Previous hands-on academic or industry research experience is preferred
    • Highly detail-oriented, data-driven, and curious
    • Applicants must have authorization to work in the U.S.

    The estimated annual base salary range for this role is $67,000 to $80,000. Individual compensation decisions will be based on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. We offer a wide range of benefits including a retirement savings plan (with company match), paid vacation, holidays, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.

    About Empirico: Empirico is a biotechnology company that discovers and develops novel medicines designed to mimic naturally-occurring genetic variants that confer beneficial effects on health and disease. Empirico’s two foundational technology platforms – the Precision Insights Platform™ for genetically-validated target discovery, and the siRCH™ platform for the discovery and development of siRNA medicines – are used separately and in tandem to enable Empirico and our collaborators from the discovery and validation of novel targets to clinically-viable therapeutics. Empirico’s exceptional internal capabilities, augmented by those of its partners, are driving the advancement of a growing and differentiated pipeline of wholly-owned and partnered programs. Empirico is headquartered in San Diego, CA with a major second site in Madison, WI.

    We’re striving to build a strong culture of inclusivity, transparency and collaboration at Empirico, where our diverse and equitable workforce is empowered to contribute to our mission. We always seek the best candidate for the position and encourage you to apply even if your experience or qualifications don’t match up exactly with the job description. Empirico is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

    To All Agencies: Please do not contact any employee of Empirico about this position. All resumes submitted by agencies to any employee of Empirico via-email or in any form and by any method will be deemed the sole property of Empirico, unless such agencies were engaged by Empirico for this position and a valid agreement is in place.

    APPLY NOW
  • Senior Manager/Associate Director/Director - Laboratory Animal Resources (LAR)

    Madison, WI
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    Position Description: Empirico, a biotechnology company that combines unmatched expertise in human genetics-driven target discovery with world-class capabilities in siRNA drug discovery, is looking for a talented Laboratory Animal Resources (LAR) professional to lead our vivarium operations and team in support the Company’s discovery and development programs.

    Responsibilities:

    Your responsibilities will include supervising and contributing to daily vivarium activities and operations. You will be expected to –

    • Work with the LAR team to ensure that animals receive care in accordance with applicable regulations, policies, and experimental protocols
    • Uphold safety and quality standards and ensure compliance with regulatory requirements
    • Conduct regular audits and update SOPs to address findings
    • Oversee maintenance and certification of vivarium equipment
    • Contribute to writing lab SOPs, methods, and protocols
    • Support in vivo Research, such as PKPD and disease model studies, and maximize utilization of vivarium capacity
    • Perform injection techniques, dosing, tissue collection, blood collection, and other requested animal-related procedures
    • Collaborate on study planning and execution, such as experimental design and specialized assays, and engage in data analysis, quality testing, and report preparation
    • Support staff and their development by conducting routine performance reviews, providing guidance, fostering career growth, and delivering training

    Education and Experience Requirements:

    • This position requires a Master’s degree in Animal Science or a related discipline with a combination with at least 4 years hands-on in vivo experience, or a Bachelor’s degree in combination with at least 6 years hands-on in vivo experience
    • 2+ years of experience in managing a vivarium is required
    • Experience in developing and implementing staff training programs
    • Experience in preparing a facility for AAALAC accreditation is preferred
    • AALAS certification at LATG level or higher is preferred
    • Applicants must have authorization to work in the U.S.

    Skills Requirements:

    • Experience in rodent handling
    • Strong leadership and management skills
    • Effective written and oral communication skills, including the ability to apply relevant scientific concepts and terminology
    • Affinity for animals and respect for their welfare is essential
    • Critical thinking, problem-solving, and the ability to adapt to a dynamic team environment
    • Self-motivated with a commitment to quality and safety
    • Skilled in conflict resolution, performance management, and talent development
    • Proficient in Microsoft Office Suite, with general computer literacy

    Working Conditions and Physical Requirements:

    • Ability to lift up to 25 pounds
    • Manual dexterity required for lab work
    • Willingness to work overtime, weekends, and holidays as needed

    The estimated base salary range for this role is $75,000 to $130,000. Individual compensation decisions will be based on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. We offer a wide range of benefits including a retirement savings plan (with company match), paid vacation, holidays, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.

    About Empirico: Empirico is a biotechnology company that discovers and develops novel medicines designed to mimic naturally-occurring genetic variants that confer beneficial effects on health and disease. Empirico’s two foundational technology platforms – the Precision Insights Platform™ for genetically-validated target discovery, and the siRCH™ platform for the discovery and development of siRNA medicines – are used separately and in tandem to enable Empirico and our collaborators from the discovery and validation of novel targets to clinically-viable therapeutics. Empirico’s exceptional internal capabilities, augmented by those of its partners, are driving the advancement of a growing and differentiated pipeline of wholly-owned and partnered programs. Empirico is headquartered in San Diego, CA with a major second site in Madison, WI.

    We’re striving to build a strong culture of inclusivity, transparency and collaboration at Empirico, where our diverse and equitable workforce is empowered to contribute to our mission. We always seek the best candidate for the position and encourage you to apply even if your experience or qualifications don’t match up exactly with the job description. Empirico is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

    To All Agencies: Please do not contact any employee of Empirico about this position. All resumes submitted by agencies to any employee of Empirico via-email or in any form and by any method will be deemed the sole property of Empirico, unless such agencies were engaged by Empirico for this position and a valid agreement is in place.

    APPLY NOW
  • Associate Laboratory Animal Resources (LAR) Scientist

    Madison, WI
    READ MORE READ LESS

    Position Description: Empirico, a biotechnology company that combines unmatched expertise in human genetics-driven target discovery with world-class capabilities in siRNA drug discovery, is looking for a talented Laboratory Animal Research (LAR) professional to support our vivarium operations.

    Responsibilities:

    Your responsibilities will include contributing to daily vivarium activities and operations. You will be expected to –

    • Perform daily tasks related to animal care, ensuring humane treatment of animals, including husbandry, health monitoring, and administering medications
    • Perform experimental procedures, collect samples and experimental data, and accurately maintain records
    • Collaborate with researchers and staff to design and execute experiments, prepare animal models, and analyze data
    • Assist in developing and implementing SOPs for animal care, experimental protocols, and safety guidelines
    • Maintain cleanliness and organization of laboratory and animal housing areas, following biosafety and animal welfare protocols
    • Participate in training programs to stay current with advancements in animal research and welfare standards

    Education and Experience Requirements:

    • Associate’s degree in Animal Science or a related discipline preferred
    • 2+ years of vivarium experience with responsibility for animal husbandry is required
    • Applicants must have authorization to work in the U.S.

    Skills Requirements:

    • Experience in rodent handling and proficiency with in vivo procedures, injections, blood draws, data collection, and analysis are required
    • Effective written and oral communication skills, including the ability to apply relevant scientific concepts and terminology
    • Affinity for animals and respect for their welfare is essential
    • Critical thinking, problem-solving, and the ability to adapt to a dynamic team environment
    • Self-motivated with a commitment to quality and safety
    • Proficient in Microsoft Office Suite, with general computer literacy

    Working Conditions and Physical Requirements:

    • Ability to lift up to 25 pounds
    • Manual dexterity required for lab work
    • Willingness to work overtime, weekends, and holidays as needed

    The estimated base salary range for this role is $50,000 to $70,000. Individual compensation decisions will be based on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. We offer a wide range of benefits including a retirement savings plan (with company match), paid vacation, holidays, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.

    About Empirico: Empirico is a biotechnology company that discovers and develops novel medicines designed to mimic naturally-occurring genetic variants that confer beneficial effects on health and disease. Empirico’s two foundational technology platforms – the Precision Insights Platform™ for genetically-validated target discovery, and the siRCH™ platform for the discovery and development of siRNA medicines – are used separately and in tandem to enable Empirico and our collaborators from the discovery and validation of novel targets to clinically-viable therapeutics. Empirico’s exceptional internal capabilities, augmented by those of its partners, are driving the advancement of a growing and differentiated pipeline of wholly-owned and partnered programs. Empirico is headquartered in San Diego, CA with a major second site in Madison, WI.

    We’re striving to build a strong culture of inclusivity, transparency and collaboration at Empirico, where our diverse and equitable workforce is empowered to contribute to our mission. We always seek the best candidate for the position and encourage you to apply even if your experience or qualifications don’t match up exactly with the job description. Empirico is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

    To All Agencies: Please do not contact any employee of Empirico about this position. All resumes submitted by agencies to any employee of Empirico via-email or in any form and by any method will be deemed the sole property of Empirico, unless such agencies were engaged by Empirico for this position and a valid agreement is in place.

    APPLY NOW
  • General Application

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    We’re always looking for talented people who share our passion for improving patients’ lives. If you feel driven to contribute but don’t see an open position that fits your specific background and skills, let us know using the link below.

    APPLY NOW
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